So, that brings me to where I left off in my last newsletter. The next point I want to emphasize is that the vaccines do not induce the same immune responses as infection.
Briefly, without getting too much into the details, both the mRNA vaccines (Pfizer and Moderna) and the vector vaccine (Johnson & Johnson) work by injecting genetic instructions into the body that enter the cells and induce them to produce the spike protein of the original Wuhan strain of SARS-CoV-2 — which is now extinct outside of laboratories.
Hence, the immune responses induced by vaccination only include responses to the spike protein, whereas infection induces immune responses to the whole virus.
Importantly, T cell responses appear to focus at least equally, if not predominantly, on the nucleocapsid and membrane proteins.
The route of exposure is important, too. Infection occurs through the respiratory tract, and induction of mucosal immunity in the tract lining is important for limiting transmissibility of the virus from an infected individual.
Scientists from the start anticipated that getting a shot in the arm would not induce strong mucosal immunity, both because of the narrow focus on the spike and because vaccines largely bypass innate immune defenses and do not induce the same adaptive immune responses due to the differing route of delivery.
Tellingly, as I’ve reported on my social media (see links to follow me at the foot of any newsletter), the CDC just updated its public health guidance for fully vaccinated individuals to tell them that they need to start wearing masks again when in public indoor settings.
In Israel, the first country to implement a mass vaccination campaign aiming to vaccinate the entire eligible population, according to mainstream Israeli news media, health ministry data show that half of recent COVID-19 cases are fully vaccinated individuals.
Israeli military intelligence has also warned since January that, due to the suboptimal immunity conferred by vaccines, the mass vaccination campaign could put evolutionary pressure on SARS-CoV-2 leading to the emergence of a variant that can escape vaccine-conferred immunity.
That gets us into the third argument used to support the CDC’s recommendation for people who are already immune to still get vaccinated, which is that vaccines offer better protection against variants.
We’ll thoroughly debunk that lie, too, in due time. That’s all for now!